Electric Literature of 39906-04-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
As shown in step 10-v of Scheme 10, to a solution of 4,6-dichloro-2-methyl-pyrimidin-5-amine (14.04 g, 78.88 mmol) stirred in methanol-d4 (140.4 mL) was added formic acid-d2 (7.77 g, 161.7 mmol) and Pd black (765 mg, 7.19 mmol, wetted in methanol-d4), followed by triethylamine (16.36 g, 22.53 mL, 161.7 mmol). The reaction mixture was sealed in a tube and stirred at RT overnight. The mixture was then filtered and concentrated under reduced pressure. Et2O (250 mL) was added and the mixture stirred for 1 hour at RT. The resulting solids were filtered and washed with Et2O (*2). The filtrate was concentrated under reduced pressure to yield 4,6-dideutero-2-methyl-pyrimidin-5-amine (compound 2043, 5.65 g, 65% yield) as a light yellow solid: 1H NMR (300 MHz, DMSO-d6) delta 5.25 (s, 2H), 2.40 (s, 3H). This compound was used in subsequent steps without further purification.
According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Charifson, Paul S.; Cottrell, Kevin Michael; Deng, Hongbo; Duffy, John P.; Gao, Huai; Giroux, Simon; Green, Jeremy; Jackson, Katrina Lee; Kennedy, Joseph M.; Lauffer, David J.; Ledeboer, Mark Willem; Li, Pan; Maxwell, John Patrick; Morris, Mark A.; Pierce, Albert Charles; Waal, Nathan D.; Xu, Jinwang; US2013/281431; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia