Synthetic Route of 49844-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, molecular formula is C5H5ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 4-chloro-2-(methylthio)-pyrimidine (21,9.90 g, 61.6 mmol) in MeOH (28 mL) and MeCN (20 mL)mixed solution, NBS (13.16 g, 73.9 mmol) was added(2 ¡Á 6.58 g). After the additions, the reaction mixture wasstirred at room temperature. After quenching with saturatedNa2SO3solution, the solution was extracted with DCMand saturated NaHCO3solution three times. The combinedorganic phases were dried over MgSO4,filtered, and concentrated in vacuo. The residue was purified by passingthe organic extract through a silica gel column using PE/EA(25:1) to give the product 22 (Elliott 1981). White solid;yield 73%; m.p. 48.5-50.1 C; 1H NMR (300 MHz, CDCl3)delta 8.54 (s, 1H), 2.55 (s, 3H); 13C NMR (75 MHz, CDCl3)delta172.1, 159.5, 114.1, 14.7; HRMS ([M + H]+): m/z calcd for[(C5H4BrClN2S) + H]+: 240.90254, found: 240.90203.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine.
Reference:
Article; Li, Shu-ting; Chen, Jun-qing; Feng, Cheng-liang; Yang, Wan-feng; Ji, Min; Chemical Papers; vol. 73; 12; (2019); p. 3043 – 3051;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia