The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7752-78-5, name is 5-Bromo-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 7752-78-5
c) 1-Isopropyl-3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one Through a suspension of 1 -isopropyl-3 ,3 -dimethyl-6-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)indolin-2-one (220 mg, 668 imol), 5-bromo-2-methylpyrimidine (139 mg, 802 imol) and 2Maqueous Na2CO3 solution (668 tl, 1.34 mmol) in dioxane (3.0 ml) was bubbled argon for 5 minutes. [1,1 ?-Bis(diphenylphosphino)ferroceneldichloropalladium(II), complex with dichloromethane (1:1) (27.3 mg, 33.4 imol) was added and argon was bubbled through again for 5 minutes. The reaction mixture was heated to 110 °C for 20 hous. The solvent was evaporated and the residue was purified by silica gel chromatography using EtOAc/ heptane as eluentfollowed by amino silica gel chromatography using EtOAc/ heptane as eluent. The titlecompound was obtained as off-white solid (115 mg).MS ESI (m/z): 296.3 [(M+H)j.1H NMR (CDC13, 300 MHz): oe = 8.83 (s, 2H), 7.32 (d, J=7.7 Hz, 1H), 7.23 – 7.15 (m, 1H), 7.12(d, J=1.4 Hz, 1H), 4.69 (spt, J=7.1 Hz, 1H), 2.81 (s, 3H), 1.52 (d, J=7.1 Hz, 6H), 1.39 (s, 6H).
With the rapid development of chemical substances, we look forward to future research findings about 7752-78-5.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BRUNNER, Daniela; HILPERT, Hans; KOLCZEWSKI, Sabine; LIMBERG, Anja; MALBERG, Jessica; PRINSSEN, Eric; RIEMER, Claus; SHANKAR, Bavani G.; STOLL, Theodor; WO2014/202493; (2014); A1;,
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