Electric Literature of 54326-16-8 ,Some common heterocyclic compound, 54326-16-8, molecular formula is C4H3ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 12 5-Chloro-1-(1-oxo-1-phenylprop-2-yl)pyrimidin-2-one A solution of 5-chloropyrimidin-2-one (394 mg) and alpha-bromopropiophenone (0.5 ml) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for 2.75 hours. The solution was evaporated and the residue was triturated with water (50 ml) giving an oily solid. This was extracted with ethyl acetate (3*50 ml). The combined extracts were washed with brine (50 ml), dried (MgSO4) and evaporated to a gum. This was crystallized from acetone-petrol (b.p. 40-60) to give the title pyrimidinone (306 mg,); m.p. 125-127; lambdamaxEtOH 232 nm (epsilon 15400), 245 nm (epsilon 15480), 335 nm (epsilon 3970).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54326-16-8, its application will become more common.
Reference:
Patent; Glaxo Group Limited; US4636509; (1987); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia