Electric Literature of 1993-63-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1993-63-1, name is 5-Fluoro-2-methoxypyrimidin-4-amine, molecular formula is C5H6FN3O, molecular weight is 143.12, as common compound, the synthetic route is as follows.
1 Added 14.3 g to the reaction device4-amino-5-fluoro-2-methoxypyrimidine (0.10 mol),17.55gIsothiocyanatoFormic acidMethyl ester(0.15mol) and 100gEthyl acetate, stirring and warming to reflux, reaction 18h, unseparated[(2-Methoxy-5-fluoropyrimidin-4-yl)amino]thiocarbonylcarbamate methyl ester.Hydroxylamine hydrochloride aqueous sodium hydroxide solution is added to the reacted material[Contains 13.9g of hydroxylamine hydrochloride (0.20mol), 8g of sodium hydroxide (0.20mol)And 70g of water], after the addition of reflux reaction continued 6h.After the reaction is completed, it is lowered to room temperature (15 to 25C, the same below).Stirring, cooling, suction filtration, washing with water, and drying yield 16.8 g of pale yellow solid5-Methoxy-8-fluoro-[1,2,4]-triazolo[1,5-c]pyrimidin-2-amine,The yield was 91.8%.
Statistics shows that 1993-63-1 is playing an increasingly important role. we look forward to future research findings about 5-Fluoro-2-methoxypyrimidin-4-amine.
Reference:
Patent; Jiangsu Nongyong Hormone Engineering Technology Research Center Co., Ltd.; Nanjing Gaoheng Biological Technology Co., Ltd.; Kong Fanlei; Sun Yonghui; Zhang Yuanyuan; Shi Yueping; Gao Jianhong; (5 pag.)CN107602566; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia