Reference of 54-20-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54-20-6, name is 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H3F3N2O2, molecular weight is 180.09, as common compound, the synthetic route is as follows.
EXAMPLE 7 2′-Deoxy-5-trifluoromethyl-4′-thiouridine Starting with 5-trifluoromethyluracil, this compound was prepared in a similar manner to that described in Example 5. 5-trifluoromethyluracil is commercially available. A sample of this compound of anomer ratio beta/alpha ca. 8:1 was obtained by trituration of the crude deprotected nucleoside mixture with acetone, filtration and evaporation. 1 H-200 MHz NMR DMSO-d6, delta:11.8 (br s, 1H, NH); 8.83 (s, 1H, beta-6-H); 6.2 (t, 1H, beta-1′-H); 5.2-5.4 (m, 2H, beta-3’+5′-OH); 4.25-4.4 (m, 1H, beta-3′-H); 3.5-3.8 ((m, 2H, beta5’H); 3.0-3.5 (m, 4’H obscured by solvent); 2.2-2.4 (m, 2H, beta-5′-H2); small signals indicative of the alpha-anomer content were also observed. Mass spectrum: observed m/z 312 for C10 H11 F3 N2 O4 S.
Statistics shows that 54-20-6 is playing an increasingly important role. we look forward to future research findings about 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; University of Birmingham; US5356882; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia