Reference of 5807-14-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5807-14-7, name is 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine, molecular formula is C7H13N3, molecular weight is 139.1982, as common compound, the synthetic route is as follows.
[0119] Red solid benzyl potassium (9.6 g, 73.3 mmol) was added into the solution of 1.5.7-triaza[4.4.0]bicyclo-dec-5-ene (10.2 g, 73.3 mmol) in 350 ml of dry toluene at -40 C. The temperature was allowed to warm to room temperature and the mixture stirred for 16 hours. The colour changed via red to a white slurry. The solvents were removed in a vacuum, the product washed with 3×60 ml of ether and dried in a vacuum to obtain 10.1 g (78%) of white powder. 1H-NMR in THF-d8; delta: 3.17 (t, 4H); 2.98 (t, 4H); 1.69 (t, 4H). The potassium salt product could not be analysed with MS. Elemental analysis calc.: C 47.4%, H 6.8%, N 23.7%, K 22.1%. Elemental analysis found: C 46.0%, H 6.4%, N 23.1%.
Statistics shows that 5807-14-7 is playing an increasingly important role. we look forward to future research findings about 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine.
Reference:
Patent; Andell, Ove; Maaranen, Janne; Hoikka, Jouni; Vanne, Tiina; Rautio, Soile; US2003/225275; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia