Adding a certain compound to certain chemical reactions, such as: 1480-66-6, 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1480-66-6, blongs to pyrimidines compound. Product Details of 1480-66-6
6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine (50 mg, 0.221 mmol) and potassium thioacetate (37.9 mg, 0.331 mmol) in Dioxane (3 ml) were heated in microwave (Temp. l00C, Hold time 10 min., Pressure 300, Power 150). After cooling, excess solvent was evaporated under reduced pressure. The reaction mixture was partitioned between ethyl acetate and water. The aqueous phase was extracted again with ethyl acetate. The organic solvent was then dried over MgS04 and evaporated under reduced pressure. The combined organic layers were dried over anhydrous MgS04 and evaporated under reduced pressure. The obtained residue was taken to the next step without further purification. LC/MS: m/z 196 (M+H)+.
The synthetic route of 1480-66-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
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