Electric Literature of 612-60-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 612-60-2 as follows.
To 7-methylquinoline (25.0 g, 17.5 mmol) at 160 C. was added SeO2 (19.2 g, 175 mmol) portionwise over 5 min. The mixture was stirred at 160 C. for 8 h, then allowed to cool to room temperature. CH2Cl2 (400 mL) was added, and the mixture was filtered through a pad of CELITE. The filtrate was concentrated under reduced pressure, and the residue was purified by SiO2 gel chromatography (10:1 petroleum ether/EtOAc) to give the title compound as a yellow solid (5 g, 18%). MS (ES+): C10H7NO requires: 157 found: 158 [M+H]+
According to the analysis of related databases, 612-60-2, the application of this compound in the production field has become more and more popular.