Application of 672-41-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 672-41-3, name is 6-(Trifluoromethyl)pyrimidin-4-amine, molecular formula is C5H4F3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a cooled (0 C.) solution of 6-(trifluoromethyl)pyrimidin-4-amine (2.0 g, 12.3 mmol) in MeOH (100.0 mL) was added bromine (1.3 mL, 24.5 mmol) drop wise over a period of 10 minutes. The mixture was stirred at rt for 2 hours. The reaction was quenched with H2O and concentrated in vacuo to obtain crude HBr salt (3.57 g). The crude product was purified by reverse-phase HPLC using a XBridge C18 column (5 mum, 100*4.6 mm), mobile phase of 10-100% ACN in 20 mM NH4OH, to afford the title compound as tan solid (2.4 g, 80%). MS (ESI): mass calcd. for C5H3BrF3N3, 241.9; m/z found, 243.9 [M+H]+. 1H NMR (500 MHz, DMSO-d6) delta 8.46 (s, 1H), 8.25 (s, 1H), 7.52 (s, 1H).
According to the analysis of related databases, 672-41-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Janssen Pharmaceutica NV; Ameriks, Michael K.; Laforteza, Brian Ngo; Lebold, Terry Patrick; Ravula, Suchitra; Savall, Brad M.; Shireman, Brock T.; (70 pag.)US2018/111942; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia