As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 776-53-4, name is Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate, molecular formula is C8H11N3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 776-53-4
The mixture of ethyl 4-chloro-2-methylthio-5 -pyrimidine carboxylate (20.0 mmol), Et3N (10 ml), and 50% aq NH3. H20 (8 ml) in THF (100 mL) was stirred at room temperature for 4 h. After evaporation of the resulting residue,the mixture was diluted with H20 and extracted with EtOAc. After evaporation, get the crude amino substituted pyrimidine. To this crude amino substituted pyrimidine in THF (100 mL) was added dropwise LiA1H4 (11.0 mmol) in 30 ml Et20 at 0C. After stirring at room temperature for 8 h, H20 (3.0 mL), 2N NaOH (10 mL), and H20 (3.0 mL) were added sequentially. The crude product waspurified by column chromatography to afford intermediate alcohol 1 (73 % yield for steps).
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Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; FENG, Yangbo; LOGRASSO, Philip; ZHENG, Ke; PARK, Chul Min; WO2015/84936; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia