Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 890094-38-9
4-(4-methylpiperazinyl)phenylamine(3.8g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 3 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(6.2g) in a yield of 84.1%. 1H NMR(400 MHz, CDCl3): delta 9.02(s, 1H), 8.42(s, 1H), 7.63(s, 1H), 7.51(s, 2H), 6.95(m, 2H), 4.41(m, 1H), 3.22(t, J=4.8Hz, 4H), 2.61(t, J=4.8Hz, 4H), 2.37(s, 3H), 1.33(d, J=6.4Hz, 6H)ppm.
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Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
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