Application of 90213-67-5 , The common heterocyclic compound, 90213-67-5, name is 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C7H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(2S,3S)-Ethyl 3-aminobicyclo[2.2.2]octane-2-carboxylate hydrochloride (1.26 g, 5.40mmol) and 2,4-dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (1.10 g, 5.40 mmol) weredissolved in DMF (5 mL), then K2C03 (1.50 g, 11.00 mmol) was added. The mixture was stirredat rt overnight. The reaction was stopped, and water (50 mL) was added to quench the reaction,and the resulting mixture was extracted with EtOAc (50 mL x 2). The combined organic phaseswere washed with saturated brine (80 mL), dried over anhydrous Na2S04, filtered, and thefiltrate was concentrated in vacuo. The residue was purified by silica gel chromatograph(PE/EtOAc (v/v) = 1011) to give the title compound as a yellow solid (979 mg, 50%).MS (ESI, pos.ion) m/z: 363.2 [M+Ht;1H NMR (400 MHz, CDCb) 8 (ppm): 6.87 (d, J = 3.4 Hz, 1H), 6.41 (s, 1H), 5.32 (s, 1H), 4.63 (s,1H), 4.21 (q, J = 7.1 Hz, 2H), 3.76 (s, 3H), 2.39 (d, J = 4.9 Hz, 1H), 1.96- 1.52 (m, 10H), 1.26(t, J = 7.0 Hz, 3H).
The synthetic route of 90213-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia