Adding a certain compound to certain chemical reactions, such as: 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6299-25-8, blongs to pyrimidines compound. Application In Synthesis of 4,6-Dichloro-2-(methylthio)pyrimidine
(1) n-Butyl lithium(1.7M hexane solution, 295 mL) was added dropwise to a solution of diisopropylamine(47.7 g) in THF(1.4 L) at -78C under nitrogen atmosphere for 30 minutes and stirred for additional 30 minutes. A solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine(40.0 g) in THF(200 mL) was added dropwise to the reaction solution for an hour and stirred for an additional hour. The reaction solution was poured into dry ice(800 g) slowly and the mixture was stirred for 2 hours. Hydrochloric acid(1N) was added slowly, ethyl acetate was added thereto and the mixture was washed with water and brine. The aqueous layer was extracted with ethyl acetate, the combined organic layer was dried over magnesium sulfate and the solvent was distilled away. Hexane was added and the solid was triturated and dried to give 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid(45.51 g) as a pale brown solid. APCI-MS(m/e):237/239[M-H]-.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-25-8, its application will become more common.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1970373; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia