Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione《Nucleosides. LXXVIII. Synthesis of some 6-substituted uracils and uridines by the Wittig reaction》 was published in 1972. The authors were Klein, Robert S.;Fox, Jack J., and the article was included in《Journal of Organic Chemistry》. The author mentioned the following in the article:
Orotaldehyde (I) was treated with various alkylidene phosphoranes to afford α,β-unsaturated 6-substituted uracils. 6-Chloromethyluracil was converted to the 6-triphenyl-phosphonium salt (II) by reaction with Ph3P. This salt gave 6-styryluracil when treated with PhCHO. With I, II afforded 1,2-bis-(6-uracilyl)ethene which was converted to 1,2-bis-(6-uracilyl)ethane. With HCHO, II yielded 6-vinyluracil (III) which was polymerized to poly(6-vinyluracil). Bromination of III afforded the 5-bromo analog exclusively. With NaHSO3, III was converted quant. to the Na salt of 2-(6-uracilyl)ethanesulfonic acid. Synthesis of 6-methylcytidine from N4-acetyl-6-methylcytosine by the Hg(CN)2-MeNO2 procedure was achieved and the nucleoside converted via a bisulfite adduct to 6-methyluridine which was subsequently oxidized to tri-O-acetylorotidine aldehyde (IV). With carbethoxymethylenetriphenylphosphorane, IV was converted to the Et ester of trans-3-(6-uridinyl)acrylic acid. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia