Application of Pyrimidine-5-carbaldehyde

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10070-92-5, its application will become more common.

Related Products of 10070-92-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10070-92-5 as follows.

Step 1 : Pyrimidin-5-ylmethanolPyrimidine-5-carboxaldehyde (14.97 g, 138 mmol) in methanol (80 mL) at 0 0C was treated portionwise with sodium borohydride (5.24 g, 138 mmol). When the addition of sodium borohydride was complete the mixture was stirred for 1 hour at 0 0C. The mixture was quenched carefully with acetone and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 4OM, eluting with 5% methanol in dichloromethane to give pyrimidin-5-ylmethanol as a white crystalline solid.1H NMR (CDCl3): delta 9.18 (s, 1 H), 8.78 (s, 2 H), 4.81 (s, 2 H) MS: m/e 111.04 (M + H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10070-92-5, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2009/45381; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia