The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 16234-10-9
4-Chlorothieno[3, 2-d]pyrimidine VlTo a solution of 6.12 ml of dimethylformannide in 45 ml of methylene chloride is added dropwise at 25C a solution of 9.95 ml of oxalyl chloride in 45 ml of methylene chloride. Subsequently, 5.5 g of compound Vila are added and then the mixture is heated at reflux for 2.5 hours. The reaction mixture is added cautiously to water and extracted three times with methylene chloride. The combined organic phases are dried over sodium sulphate and, after filtration, concentrated under reduced pressure. After drying under reduced pressure, 4.9 g of compound Vl are obtained as a crude product, which is reacted further without further purification.NMR (300 MHz, DMSO-d6): delta = 7.73 (1 H), 8.57 (1 H), 9.01 (1 H).
With the rapid development of chemical substances, we look forward to future research findings about 16234-10-9.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2009/7421; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia