In an article, author is Hu, Zilun, once mentioned the application of 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category, Safety of 6-Aminopyrimidine-2,4(1H,3H)-dione.
Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno [3,4-c] pyridine derivatives as potent and selective dual ROCK inhibitors
A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno [4,3-d] pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described. Optimization led to compounds with sub-nanomolar inhibitory affinity for both kinases and excellent kinome selectivity. Compound 19 exhibited ROCK1 and ROCK2 IC50 of 0.67 nM and 0.18 nM respectively.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia