Prabhakar, Virupakshi; Babu, Sangu Jagadish; Jyothi, Sangu V. N. Lalitha Siva; Lahari, Sangu V. N.; Bandi, Venkateswarlu published the artcile< Synthesis, structural elucidation and anti-bacterial evaluation of some novel heterocyclic molecules derived from thieno[2,3-d]pyrimidine as a core unit>, Formula: C6H2Cl2N2S, the main research area is pyrazolyl thienopyrimidine preparation antibacterial antifungal.
A series of novel 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-substituted phenyl/heterocyclic thieno[2,3-d]pyrimidine derivatives I (R = Ph, 4-MeOC6H4, indol-5-yl, etc.) were synthesized by a facile five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The final compounds were screened for their antibacterial activity against Bacillus subtilis and Staphylococcus aureus from Gram pos. group of bacteria and Escherichia coli and Klebsiella pneumoniae from Gram neg. group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Antibacterial and antifungal activities were evaluated and compared with the standard drugs Such as Amoxicillin and Ketoconazole. From antibacterial and antifungal activity screening results, it has been observed that compounds I (R = 2-thienyl, indol-5-yl, 4-F3CC6H4, 3-pyridyl) exhibited good activity.
Organic Chemistry: Current Research published new progress about Antibacterial agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Formula: C6H2Cl2N2S.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia