Acetylinic ketones. Part II. Reaction of acetylenic ketones with nucleophilic nitrogen compounds was written by Baddar, F. G.;Al-Hajjar, F. H.;El-Rayyes, N. R.. And the article was included in Journal of Heterocyclic Chemistry in 1976.COA of Formula: C16H13N3 This article mentions the following:
PhCCCOR [I, R = Ph, C6H4Me-p, C6H4Cl-m, p, C6H4OMe-p, 3,4-(methylenedioxy)phenyl] reacted with H2NNHCO2R1 (R1 = Ph, Et) to give RCOCH:CPhNHNHCO2R1, which were cyclized with Ac2O to give the pyrazolecarboxylates II, which on hydrolysis-decarboxylation with MeOH-NaOH gave the aromatic pyrazoles III; I also reacted with NH2C(:NH)NH2 to give the pyrimidines IV; similarly, the pyrimidines V (Z = S, O) were prepared from heating PhCCCOPh with H2NC(:Z)NH2. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.COA of Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia