Balzarini, J. et al. published their research in Nucleic Acids Symposium Series in 1985 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Computed Properties of C10H13FN2O5

Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2′-deoxyuridine and related compounds was written by Balzarini, J.; De Clercq, E.; Ayusawa, D.; Shimizu, K.; Seno, T.. And the article was included in Nucleic Acids Symposium Series in 1985.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

Mouse mammary carcinoma FM3A cells deficient in thymidine kinase  [9002-06-6] were transformed by a cloned gene for herpes simplex virus type 1 thymidine kinase. Among several antiherpetic nucleoside analog, (E)-5-(2-bromovinyl)-2′-deoxyuridine  [69304-47-8], (E)-5-(2-iodovinyl)-2′-deoxyuridine  [69304-48-9], and (E)-5-(2-bromovinyl)-2′-deoxycytidine  [74131-09-2] inhibited the growth of the transformed cells at concentrations 5000- to 20000-fold lower than those required to inhibit the growth of their corresponding wild-type cells. The selective inhibitory action of these compounds was due to a specific phosphorylation by the viral thymidine kinase. From the transformed cells, thymidine-auxotrophic mutants that are deficient in thymidylate synthase were isolated. These mutant cell lines should prove useful in elucidating the mechanism of action of the antiherpetic nucleoside analogs. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3