On December 1, 2011, Barba, Oscar; Bell, James Charles; Dupree, Tom Banksia; Fry, Peter Timothy; Bertram, Lisa Sarah; Fyfe, Matthew Colin Thor; Gattrell, William; Jeevaratnam, Revathy Perpetua; Keily, John; Krulle, Thomas Martin; Mcdonald, Russell Walker; Morgan, Trevor; Rasamison, Chrystelle Marie; Schofield, Karen Lesley; Stewart, Alan John William; Swain, Simon Andrew; Withall, David Matthew published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of heteroarylpiperidinylmethoxypyrimidinylpyrrolidinylamine derivatives and analogs for use as GPR119 antagonists. And the patent contained the following:
Title compounds I [A = para-substituted Ph or para-substituted heteroaryl containing 1 to 3 N atoms; each Q independently = (CHR9)p; X = O, CH2, NH, etc.; Y = O, CH2, N-alkyl, etc.; Z = CO2aryl, SO2heteroaryl, C(O)alkyl, etc.; R1 = H, halo, CN, alkyl, etc.; R2 = (un)substituted Ph, pyridyl, N-pyrazolyl, etc.; R9 = H, halo, OH, alkyl, etc.; R11 = H, halo, alkyl, haloalkyl, or alkoxy; n = 0 or 1; each p independently = 0 to 2; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as GPR119 antagonists. Thus, e.g., II·HCl was prepared by a multistep procedure (preparation given). Select I were evaluated in GPR119 yeast reporter assays (data given). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine
The Article related to pyrimidinylpyrrolidinylamine piperidinylmethoxy derivative preparation gpr119 antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Chloro-5-isopropylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia