The author of 《Useful preparations involving the reactions of nucleophiles with trimethylammonio derivatives of nitrogen heterocycles》 were Barlin, G. B.; Young, A. C.. And the article was published in Journal of the Chemical Society in 1972. Quality Control of 2-Methoxy-5-nitropyrimidine The author mentioned the following in the article:
Alkoxy, amino, propylamino, hydrazino, mercapto, fluoro, and cyano derivatives of pyridine, pyrimidine, quinoline, quinazoline, and purine were prepared by treatment of the corresponding trimethylammonio compound with the appropriate nucleophile; thus, 71% 4-(propyl-amino)pyrimidine was prepared from trimethyl-4-pyrimidinyl-ammonium salt and PrNH2. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Quality Control of 2-Methoxy-5-nitropyrimidine)
2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2-Methoxy-5-nitropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia