Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-Ones and Their Use in Heterocycle Synthesis was written by Baxendale, Ian R.;Schou, Soeren C.;Sedelmeier, Joerg;Ley, Steven V.. And the article was included in Chemistry – A European Journal in 2010.Computed Properties of C16H13N3 This article mentions the following:
The palladium-catalyzed acylation of terminal alkynes gave yne-ones. The yne-ones were transformed into various heterocycles. The reactions are performed as a continuous-flow procedure by using a com. available pumping system and heated flow coils in combination with a suite of packed Omnifit glass tubes containing appropriate scavenger materials to ensure the quality of the final product. E.g., reaction of acid chloride 4-FC6H4COCl and terminal acetylene PhCCH, catalyzed by Pd(OAc)2, gave 80% 1-(4-fluorophenyl)-3-phenylprop-2-yn-1-one. The yne-ones were used to prepare heterocycles. Thus, a hydrazine input stream was used to prepare pyrazoles in a single operation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Computed Properties of C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia