Beall, Edward published the artcileEffects of the backbone and chemical linker on the molecular conductance of nucleic acid duplexes, Related Products of pyrimidines, the publication is Journal of the American Chemical Society (2017), 139(19), 6726-6735, database is CAplus and MEDLINE.
Scanning tunneling microscope break junction measurements were used to examine how the mol. conductance of nucleic acids depends on the composition of their backbone and the linker group to the electrodes. Mol. conductances of 10 base-pair-long homoduplexes of DNA, aeg-PNA, γ-PNA, and a heteroduplex of DNA/aeg-PNA with identical nucleobase sequence were measured. The mol. conductance was found to vary by 12-13-fold with the change in backbone. Computational studies showed that the mol. conductance differences between nucleic acids of different backbones correlated with differences in backbone structural flexibility. The mol. conductance was also measured for duplexes connected to the electrode through 2 different linkers, one directly to the backbone and one directly to the nucleobase stack. While the linker caused an order-of-magnitude increase in the overall conductance for a particular duplex, the differences in the elec. conductance with backbone composition were preserved. The highest mol. conductance value(0.06G0) was measured for aeg-PNA duplexes with a base stack linker. These findings revealed an important new strategy for creating longer and more complex electroactive, nucleic acid assemblies.
Journal of the American Chemical Society published new progress about 169396-92-3. 169396-92-3 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide,Others,PNA, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C26H26N4O7, Related Products of pyrimidines.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia