On August 17, 2006, Beard, Charles D.; Lee, Ving J.; Whittle, C. Ed published a patent.Related Products of 89792-07-4 The title of the patent was Process for the preparation of aza-annelated pyrroles, thiophenes and furans as potential bioisosteres of indole, benzofuran and benzothiophene scaffolds. And the patent contained the following:
A process for the preparation of aza-annelated pyrroles, thiophenes and furans I [wherein T = (un)substituted NH, O or S; R2 = H, (halo)alkyl, (un)substituted aryl, etc.; W, X, Y, Z = (un)substituted CH or N with limitations; D = H or Br], which are potentially useful as bioisosteres of indole, benzofuran and benzothiophene scaffolds, is disclosed. The process comprises coupling iodides II with acetylene compounds CHCCH2R2 or silyl group-protected acetylene such as CHC-TMS, and cyclizing the resultant alkynes in protic solvents. Key features of the method include regioselective substitution in the iodine sites and tolerance of a wide range of sensitive functional groups. For instance, regioselective Sonogashira reaction of 5-bromo-3-iodo-2-pyridinamine (preparation given) with CHC-TMS in toluene in the presence of PdCl2(PPh3)2, CuI and Et3N gave ethynylpyridinamine III in 80% yield. This compound underwent t-BuOK-mediated intramol. cyclization in refluxing t-butanol to afford 5-bromo-1H-pyrrolo[2,3-b]pyridine in 60% yield. The experimental process involved the reaction of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine(cas: 89792-07-4).Related Products of 89792-07-4
The Article related to iodopyridinamine preparation acetylene palladium copper sonogashira coupling, ethynylpyridinamine preparation intramol cyclization, pyrrolopyridine azaindole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 89792-07-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia