Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents was written by Beck, Hilary P.;Kohn, Todd;Rubenstein, Steven;Hedberg, Christine;Schwandner, Ralf;Hasslinger, Kerstin;Dai, Kang;Li, Cong;Liang, Lingming;Wesche, Holger;Frank, Brendon;An, Songhzu;Wickramasinghe, Dineli;Jaen, Juan;Medina, Julio;Hungate, Randall;Shen, Wang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Safety of 4-Chloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:
The LPA2 protein is overexpressed in many tumor cells. We report the optimization of a series of LPA2 antagonists using calcium mobilization assay (aequorin assay) that led to the discovery of the first reported inhibitors selective for LPA2. Key compounds were evaluated in vitro for inhibition of LPA2 mediated Erk activation and proliferation of HCT-116 cells. These compounds could be used to evaluate the benefits of LPA2 inhibition both in vitro and in vivo. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Safety of 4-Chloro-7-methylthieno[3,2-d]pyrimidine).
4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia