A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base was written by Beillard, Audrey;Bhurruth-Alcor, Yushma;Bouix-Peter, Claire;Bouquet, Karinne;Chambon, Sandrine;Clary, Laurence;Harris, Craig S.;Millois, Corrine;Mouis, Gregoire;Ouvry, Gilles;Pierre, Romain;Reitz, Arnaud;Tomas, Loic. And the article was included in Tetrahedron Letters in 2016.Computed Properties of C5H3ClN2O2 This article mentions the following:
While there are many protocols for the preparation of hydroxamic acids from their corresponding carboxylic acid or carboxylic ester precursors, most use strong mineral bases that can lead to carboxylic acid impurities that can be difficult to remove using standard chromatog. techniques. This problem is exacerbated when the carbonyl group is hindered. Herein, we communicate a robust hydroxylaminolysis protocol for the preparation of hydroxamic acids in high yield and purity. In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5Computed Properties of C5H3ClN2O2).
5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C5H3ClN2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia