Synthesis of pyrimidines and thiazolo[5,4-d]pyrimidines. III. N. M. R. spectrum of thiazolo[5,4-d]pyrimidine was written by Benedek-Vamos, M.;Promel, R.. And the article was included in Tetrahedron Letters in 1969.Safety of 5-Aminopyrimidin-4(3H)-one This article mentions the following:
Condensation of H2NCH:NH and EtO2CC(NO2):CHOEt in EtOH-NaOEt gave 4-hydroxy-5-nitropyrimidine, m. 190-2°, which was reduced catalytically (Pd-C) to 5-amino-4-hydroxypyrimidine, m. 206-8°. Subsequent treatment with P2S5 in boiling C5H5N gave a high yield of 5-amino-4-mercaptopyrimidine, m. 207° (decomposition), cyclized by refluxing in DCO2D 35 min. to yield 33% 2-deuteriothiazolo[5,4-d]pyrimidine (I). Oxidation of 7-hydrazinothiazolo[5,4-d]pyrimidine with AgOAc in D2O yielded 21% 7-deuteriothiazolo[5,4-d]pyrimidine (II). I, II, and the parent compound thiazolo[5,4-d]pyrimidine (III) were examined in CDCl3 at 5.9% concentration and the chem. shifts for H-2, H-5, and H-7 tabulated. The proton in the 2-position is most shielded and that in the 7-position is assigned to the low field singlet. Going downfield, the correct order of chem. shifts is H-2, H-5, H-7. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Safety of 5-Aminopyrimidin-4(3H)-one).
5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 5-Aminopyrimidin-4(3H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia