Synthesis, Characterization, and Anti-Amoebic Activity of N-(Pyrimidin-2-yl)benzenesulfonamide Derivatives was written by Bhat, Abdul Roouf;Arshad, Mohammad;Lee, Eun Ju;Pokharel, Smritee;Choi, Inho;Athar, Fareeda. And the article was included in Chemistry & Biodiversity in 2013.Related Products of 40230-24-8 This article mentions the following:
A new series of N-(pyrimidin-2-yl)benzenesulfonamide derivatives, were synthesized from pyrimidin-2-amines, with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chem. structures of the compounds were elucidated by elemental anal., FTIR, 1H- and 13C-NMR, and ESI mass-spectral data. In vitro anti-amoebic activity was evaluated against HM1 : IMSS strain of Entamoeba histolytica. The IC50 values were calculated by using the double dilution method. The results were compared with the IC50 value of the standard drug ‘metronidazole’. The selected compounds were tested for their cytotoxic activities by cell-viability assay using H9C2 cardiac myoblasts cell line, and all the compounds displayed remarkable >80% viabilities to a concentration of 100 μg/mL. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Related Products of 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia