In 2022,Bhuyan, Amar Jyoti; Bharali, Sourav Jyoti; Sharma, Abhilash; Dutta, Dhiraj; Gogoi, Pranjal; Saikia, Lakhinath published an article in Journal of Organic Chemistry. The title of the article was 《Copper-Catalyzed Direct Syntheses of Phenoxypyrimidines from Chloropyrimidines and Arylboronic Acids: A Cascade Avenue and Unconventional Substrate Pairs》.Reference of 4,6-Dichloropyrimidine The author mentioned the following in the article:
This synthetic methodol. for phenoxypyrimidines I (R = Ph, 2-methylphenyl, 3-nitrophenyl, etc.; R1 = H, Cl; X = N, CH;) and Et 4-[(4-hydroxyphenyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate that avoids the direct use of phenols or their salts was described. In contrast to the general trend of delivering Suzuki-Miyaura cross-coupling products in reactions between aryl or alky halides and arylboronic acids, the substrate pairs used herein (chloropyrimidines and arylboronic acids RB(OH)2) led to C-O bond formation under the reaction conditions. In total, 25 phenoxypyrimidines I and Et 2-(methylthio)-4-phenoxypyrimidine-5-carboxylate, 6-(4-aminophenoxy)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, 2-((6-methoxypyridin-3-yl)oxy)pyrimidine were successfully synthesized using the described protocol, 6 of which had a structural resemblance to etravirine such as N-methyl-N-(6-phenoxypyrimidin-4-yl)pyrimidin-2-amine. The results came from multiple reactions, including the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Reference of 4,6-Dichloropyrimidine)
4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Reference of 4,6-Dichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia