Synthesis of 2-bromopyrimidines and 2,2′-bipyrimidines was written by Bly, Donald D.. And the article was included in Journal of Organic Chemistry in 1964.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:
2-Bromo-4,6-dimethylpyrimidine (I) was prepared from 2-amino-4,6-dimethylpyrimidine by reverse addition diazotization. Similarly, 2-amino-4-chloro-6-methylpyrimidine was diazotized to 2-bromo-4-chloro-6-methylpyrimidine (II) together with some 4-chloro-2-pyrimidinol. I was coupled with the elimination of Br to give 4,4′,6,6′-tetramethyl-2,2-bipyrimidine. II did not afford 4,4′-dichloro-6,6′-dimethyl-2,2′-bipyrimidine and work had to be suspended owing to a severe dermatitis that appeared on the author’s hands. Infrared and ultraviolet spectra of the compounds prepared are given. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine).
2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia