On August 7, 2013, Bradley, Stuart Edward; Bell, James Charles; Keily, John; Morrison, Angus; Hanrahan, Patrick Eric; Morgan, Trevor; Rasamison, Chrystelle; Curtis, Eleanor; Smyth, Donald; Bloxham, Jason; Sambrook-Smith, Colin Peter published a patent.Recommanded Product: 596114-50-0 The title of the patent was Preparation of 3-(N-heterocyclylpiperidin-4-yl)butyloxyphenyl derivatives as agonists of GPR119 and GPR40 receptors. And the patent contained the following:
Title compounds I, II and III [R3 = H, F or propyn-1-yl; R5, R6 and R7 = independently H or halogen; E = O, NR8 or S; R8 =H, Me, Et, Pr or i-propyl; V = bond, C(CH3)2, (un)substituted spirocycloalkyl or spiroheterocycle; W = CH2 or form cycloalkyl or heterocyclyl when taken together with V; A = (un)substituted Ph or heteroaryl; B = H, F, OH, propyn-1-yl, etc.; X = O, CH2, N or S; Y = CH2, (CH3)CH, FCH, CH2CH2, etc.; R9 and R10 = independently H, halogen, (un)substituted alkyl, or form azabicyclo[3.3.1]nonane, 3-oxa-7-azabicyclo[ 3.3.1]nonane or azabicyclo[3.2.1]octane when taken together; R11 = H, halogen, alkoxy or (un)substituted alkyl; p and q = 0-2; Z = Ph, benzyl, heteroaryl or CH2-heteroaryl, etc.], and their pharmaceutically acceptable salts, are prepared as agonists of GPR119 and GPR40 receptors. Compound IV was prepared by coupling reaction of compound V (preparation given) and compound VI (preparation given) followed by hydrolysis of the ester group. CompoundIV exhibited activities with EC50 values of less than 1 μM in both GPRl19 cAMP assay and GPR40 FLIPR assay. The invention compounds are useful for the treatment of type II diabetes. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Recommanded Product: 596114-50-0
The Article related to heterocyclylpiperidinylbutyloxyphenyl derivative preparation gpr119 gpr40 receptor agonist typeii diabetes, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia