Adding a certain compound to certain chemical reactions, such as: 10457-14-4, 2,4-Bis((trimethylsilyl)oxy)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10457-14-4, blongs to pyrimidines compound. SDS of cas: 10457-14-4
The reaction mixture of the compound 3 (18.0 g, 33.8 mmol) obtained in the step 2, 2,4-bis((trimethylsilyl)oxy)pyrimidine (15.2 g, 59.2 mmol) and silver trifluoromethanesulfonate (AgOTf) (13.0 g, 50.9 mmol) in acetonitrile (MeCN)/ 1,2-dichloroethene (DCE) (163 mL/163 mL) was stirred at 100 C for 5 h, cooled down to 25 C and quenched with brine. The precipitates were filtered off and the filtrate was extracted with DCM. The organic layer was dried over MgSO4, filtered and evaporated. The residue was purified by silica gel column chromatography (DCM : EtOAc = 5 : 1) to give the compound 4 (14.5 g, 64%) as a yellow solid. 1H NMR (400 MHz, CDC13) delta 8.47 (br s, 1 H), 8.07-7.92 (m, 6 H), 7.70 (d, J= 8.4 Hz, 1 H), 7.62-7.53 (m, 3 H), 7.48-7.34 (m, 6 H), 6.33 (d, J= 5.6 Hz, 1 H), 5.88 (t, J= 5.6 Hz, 1 H), 5.61 (d, J= 8.4 Hz, 1 H), 5.07-5.04 (m, 1 H), 4.93 (dd, J= 13.2, 2.8 Hz, 1 H), 4.58 (dd, J= 12.8, 3.2 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10457-14-4, its application will become more common.
Reference:
Patent; KAINOS MEDICINE, INC.; SHIN, Sunmi; KIM, Hyangmi; OH, Su-Sung; WO2015/72784; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia