Related Products of 1159818-57-1 ,Some common heterocyclic compound, 1159818-57-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 6-bromopyrimidin-4-amine (4.17 g, 24 mmol) in 100 mL of HI was added Nal (14.4 g, 96 mmol). The mixture was stirred at ambient temperature for 2 days. Then, the mixture was adjusted to pH=10 with NaOH solution, and the solid was separated and filtered to give 6-iodopyrimidin-4- amine. H NMR (400Mz, DMSO-c/6) delta (ppm): 6.85 (s, 1 H), 6.99(s, 2 H), 7.99 (s, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1159818-57-1, its application will become more common.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; JEANGUENAT, Andre; JUNG, Pierre Joseph Marcel; MUEHLEBACH, Michel; (150 pag.)WO2016/71214; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia