The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate
Toluene (40.8g) was stirred and heated to 700C. Methyl (E)-2-{2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (24.2g at 98%w/w, 0.074mols), DABCO (0.85g at 98%w/w, 0.007mols) and 2-cyanophenol (9.9g at 97.5%w/w, O.Odeltamols) were added at 10 minute intervals, maintaining the temperature at 7O0C. After a further 10 minutes DBU , (13.8g at 98%w/w, 0.09mols) was added over 5.5 minutes. During the addition the temperature went up to 78C and cooling was applied to maintain 7O0C. The reaction mixture was stirred at 700C for 90 minutes (still 35.8 area% methyl (E)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate unreacted by GC analysis). The reaction temperature was raised to 800C and stirring continued for another 90 minutes at which time the reaction was still not complete (14.2 area% methyl (E)-2- {2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate unreacted by GC analysis). The temperature was raised to 1000C and stirring continued for a further 60 minutes to complete the reaction. The reaction mixture was cooled to 700C before hot water (75C) (78.3g) was added. The mixture was stirred for 15 minutes at 70-75C, then settled and the aqueous phase separated. A second water wash (78.3g) was applied in the same way. The toluene phase (66.6g) contained methyl (J£)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (32.8%w/w), 73.3% of theory.
With the rapid development of chemical substances, we look forward to future research findings about 131860-97-4.
Reference:
Patent; SYNGENTA LIMITED; WO2008/43978; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia