Application of 1337532-51-0, Adding some certain compound to certain chemical reactions, such as: 1337532-51-0, name is 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine,molecular formula is C7H7BrN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1337532-51-0.
To a stirred solution of 3-benzyl-7-bromo-8-fluoroisoquinoline (0.13 g, 0.41 1 mmol, 1 equiv) in 1 ,4-dioxane (10 mL) was added bis(pinacolato)diboron (0.10 g, 0.41 1 mmol, 1 equiv), and potassium acetate (0.12 g, 1 .23 mmol, 3 equiv). The reaction mixture was degassed with N2 for 10 minutes. PdCl2(dppf)-CH2Cl2 adduct (0.0167 g, 0.02 mmol, 0.05 equiv) was added and the mixture was degassed with N2 for 5 minutes. The reaction mixture was stirred for 12 hour at 100 C in a sealed vessel. The reaction was cooled to room temperature. 5-bromo-7-methyl-7/-/-pyrrolo[2,3-c ]pyrimidin-4-amine (0.094 g, 0.41 1 mmol, 1 .0 equiv), saturated aqueous NaHC03 (3 mL) and PdCI2(dppf)-CH2Cl2 adduct (0.0167 g, 0.02 mmol, 0.05 equiv) was added and the reaction mixture was degassed with N2 for 5 minutes. The vessel was sealed and the reaction mixture was stirred for 8 hour at 100 C. The mixture was filtered through celite and the filtrate was evaporated to obtain crude product, which was purified by silica gel flash column chromatography. The compound eluted out in 3 % MeOH:DCM. The fractions containing product were evaporated to obtain 5-(3-benzyl-8-fluoroisoquinolin-7-yl)-7-methyl-7H^yrrolo[2,3-c ]pyrimidin-4-amine (0.012 g, 8 %) as an off-white solid. LCMS (ES) m/z = 384.2 [M+H]+. NMR (400 MHz, DMSO-d6) delta ppm 3.76 (s, 3H), 4.26 (s, 2H), 6.13 (br.s., 2H), 7.19 (t, J=6.8 Hz, 1 H), 7.27 – 7.35 (m, 4H), 7.42 (s, 1 H), 7.70 (t, J=8.0 Hz, 1 H), 7.78 – 7.80 (m, 2H), 8.15 (s, 1 H), 9.41 (s, 1 H).
According to the analysis of related databases, 1337532-51-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey; KETHIRI, Raghava Reddy; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (162 pag.)WO2018/15879; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia