Related Products of 13544-44-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
j00447j To a solution of 2,4-dichloro-5-iodo-pyrimidine (1.0 g, 3.6 mmol) in THF (20 mL) was added sodium hydroxide (1 N, 15 mL). The mixture was stirred at 25 C for 2 hours, then poured into water (100 mL) and extracted with ethyl acetate (4 x 50 mL). The combined organic phase was washed with brine (2 x 100 mL), dried with anhydrous sodium sulfate, filtered and concentrated in vacuo to give compound B-88 (0.6 g, 64% yield) as a yellow solid. ?H-NMR (MeOD, 400 MHz):8.40 (s, 1H), 7.85(s, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13544-44-0, 2,4-Dichloro-5-iodopyrimidine.
Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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