Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-40-9, name is Rosuvastatin methyl ester. A new synthetic method of this compound is introduced below., Recommanded Product: 147118-40-9
Example 663.0 g (6.0 mmol) of crystalline Form II rosuvastatin methylester are dissolved in 12 cm3 of methanol at 25 °C and while stirring, 5.9 cm3 of 1.0 M aqueous TBA solution are added at the same temperature. Thereafter five times in two-hour periods further 1.2 cm3 of 1.0 M aqueous TBA solution are added to the reaction mixture. The mixture is stirred for further 24 hours, evaporated and by adding 3 x40 cm3 eof ethylacetate, the residual water is removed by repeating azeotropic distillation three times. Into the residue thus obtained 34 cm of ethylacetate and 10 cm3 of distilled water are added. Subsequently 3.7 cm3 of 2.2 M aqueous ZnSO4 solution are added into the biphasic mixture in ten minutes at a temperature between 20 and 25 °C. After one hour stirring, the layers are separated, the organic layer is washed with 2x 10 cm of 2.2 M aqueous ZnSO4 solution and 10 cm of distilled water. The organic layer is evaporated and the remaining water is removed by repeated azeotropic distillation using ethylacetate. The suspension is cooled, filtered, washed with 3 cm of ethylacetate and dried in vacuo. Thus 2.50 g (81 percent) of crude product are obtained, which are stirred in the solutio of 1.2 mg of sodium hydroxide in 12 cm of distilled water in an argon atmosphere for 36 hours at a temperature between 0 and 5 °C. The mixture is filtered, washed with alkaline water having the same composition as described above and dried in vacuo protected from light. Thus 2.25 g (90 percent) of title product are obtained.
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Reference:
Patent; EGIS GYOGYSZERGYAR NYILVANOSAN M?KOeD? RESZVENYTARSASAG; KOVANYINE LAX, Gyoergyi; SIMIG, Gyula; VOLK, Balazs; BARTHA, Ferenc Lorant; KRASZNAI, Gyoergy; RUZSICS, Gyoergy; SIPOS, Eva; NAGY, Kalman; MOROVJAN, Gyoergy; BARKOCZY, Jozsef; KESZTHELYI, Adrienn; IMRE, Janos; BAGYINSZKI, Gabor; WO2012/73055; (2012); A1;,
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