Related Products of 149765-15-1 ,Some common heterocyclic compound, 149765-15-1, molecular formula is C11H13ClN4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-Chloro-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine 34 (150 mg, 0.59 mmol) and selectfluor (320 mg, 0.90 mmol) were placed in a round-bottom flask, followed by the addition of anhydrous MeCN (6 mL) and AcOH (0.6 mL). The mixture was then heated at 50 00 for 30 mm under N2. The mixture was then cooled by ice-water and diluted with CH2CI2 (50 mL). The organic layer was washed with sat. NaHCO3 (50 mL). The inorganic layer was separated and extracted with CH2CI2 (2 x 20 ml). The combined organic layers were dried with Na2SO4, filtered and concentrated under reduce pressure. The residue was then purified by column chromatography on silica gel (gradient DCM/MeOH, 200:1) to give 35 (48 mg, 30%) as a colorless foam. 1H NMR (300 MHz, CDCI3): 611.79 (s, 1H, NHOO), 8.25 (s, 1H, H-6), 1.39 (s, 9H, (0H3)30); 130 NMR (75 MHz, 0D013): 176.5 (NHCO), 151.3 (0-2), 150.8 (0-4), 147.8 (0-7a), 141.4 (d, 1JC,F = 248.8 Hz, 0-5), 111.2 (d, 2JC,F = 26.0 Hz, 0-6), 103.6 (d, 2JC,F = 14.9 Hz, C-4a), 40.5 (C(0H3)3), 27.7 (C(CH3)3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149765-15-1, its application will become more common.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; ANDREI, Graciela; DE JONGHE, Steven; GROAZ, Elisabetta; HERDEWIJN, Piet; LUO, Min; SCHOLS, Dominique; SNOECK, Robert; (81 pag.)WO2018/55071; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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