With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.149849-92-3, name is 2-Chloropyrimidine-4-carboxylic acid, molecular formula is C5H3ClN2O2, molecular weight is 158.54, as common compound, the synthetic route is as follows.149849-92-3
To a solution of 2-chloropyrimidine-4-carboxylic acid (1.00 g, 6.3 mmol) in anhydrousDCM (15 mL) were added oxalyl chloride (1.1 mL, 12.6 mmol) and DMF (0.1 mL) dropwise at0 C. The mixture was stirred at rt for 2 hours, and then cooled to 0 C. To the mixture were added triethylamine (1.28 mL, 9.5 mmol) and a solution of methylamine in THF (2M, 3.47 mL, 6.9 mmol) slowly at 0 C. The reaction mixture was stirred at rt for 12 hours, and then quenched with water (25 mL). The separated organic phase was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 2/1) to give the title compound as a white solid (1.06 g, 98.1%). The compound was characterized by the following spectroscopic data:LC-MS (ESI, pos. ion) m/z: 172.2 [M + H] .
Statistics shows that 149849-92-3 is playing an increasingly important role. we look forward to future research findings about 2-Chloropyrimidine-4-carboxylic acid.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; CHENG, Changchung; WO2015/169180; (2015); A1;,
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