Related Products of 16019-33-3, Adding some certain compound to certain chemical reactions, such as: 16019-33-3, name is 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde,molecular formula is C6H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16019-33-3.
A mixture of compound 7 (20.0 g, 0.1 mol), triethyl orthoformate (18.6 g, 0.12 mol), and TsOH (1.0 g, 5.8 mmol) in EtOH (100 ml) was stirred at 40C for 2 h. After completion of the reaction, aqueous Na2CO3 was added to the mixture to adjust pH to 8. The solvent was removed under reduced pressure and the residue extracted with EtOAc (300 ml), washed with water (100 ml). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the residue that was purified by column chromatography on silica gel (eluent petroleumether – EtOAc, 5:1). Yield 25.0 g (90%), colorless oil. IR spectrum, nu, cm-1: 2987, 1546, 1518, 1123, 1068, 785. 1H NMR spectrum (CDCl3), delta, ppm (J, Hz): 8.62 (1H, s,H-2); 4.80 (1H, t, J = 5.8, CH); 3.74-3.66 (2H, m,CH2CH3); 3.48-3.41 (2H, m, CH2CH3); 3.25 (2H, d, J = 5.7,CH2); 1.13 (6H, t, J = 7.0, CH2CH3). 13C NMR spectrum (CDCl3), delta, ppm: 162.7; 155.8; 132.5; 129.2; 100.9; 62.9;35.4; 15.2. Found, m/z: 287.0323 [M(35Cl)+Na]+.C10H14Cl2N2NaO2. Calculated, m/z: 287.0325. Found, m/z:289.0295 [M(35Cl,37Cl)+Na]+. Calculated, m/z: 289.0296.
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Reference:
Article; Zhang, Yu-Liu; Xu, Cheng-Tao; Liu, Ting; Zhu, Yong; Luo, Yu; Chemistry of Heterocyclic Compounds; vol. 54; 6; (2018); p. 638 – 642; Khim. Geterotsikl. Soedin.; vol. 54; 6; (2018); p. 638 – 642,5;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia