As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17180-94-8, name is 5-Chloropyrimidine, molecular formula is C4H3ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C4H3ClN2
Take 25mL reaction flask, add 5-chloropyrimidine (22.8mg, 2.0mmol),P-methoxyphenol (37.2 mg, 3.0 mmol),CuI (19.0 mg, 0.05 mmol),N-5-methoxy-1,1-biphenyl-N’-benzylaldehyde oxalate (18.0 mg 0.05 mmol)K3PO4 (466.0 mg, 2.2 mmol),The reaction flask was then evacuated and backfilled with argon three times, adding 5.0 mL of dimethylsulfoxide Sulfone as a solvent. The reaction mixture was stirred at 120 C for 30 hours. Upon completion of the reaction, after cooling to room temperature, the crude product was added to ethyl acetate and transferred to a separatory funnel, brine was added, and the organic phase was extracted and combined. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo. The residue was separated through a plug of silica gel to give the corresponding 5- (4-methoxyphenyl) pyrimidine as a yellow oil (28.3 mg, 70%).
With the rapid development of chemical substances, we look forward to future research findings about 17180-94-8.
Reference:
Patent; Funing Xunpeng New Materials Technology Co., Ltd.; Cao Shuguang; (8 pag.)CN106496109; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia