Synthetic Route of 18592-13-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, molecular weight is 160.5584, as common compound, the synthetic route is as follows.
A mixture of 132 (0.170 g; 0.35 mmol), chloromethyluracil (0.061 g; 0.38 mmol), NaI (0.057 g; 0.38 mmol) and [K2CO3] (0.053 g; 0.38 mmol) in dimethylacetamide (8 [ML)] was heated at [80C] under argon atmosphere for 17 hours. The crude mixture was evaporated and purified by flash chromatography eluting with a gradient 2-8% of 3.5 N NH3 in MeOH/methylene chloride to give after trituration in ether/heptane Example 47 as a pale brown solid. Yield: 41% MS-ESI: 615 [[M+H] +] [‘H] NMR [(CDC13)] : 1.20-1. 40 (br m, 4H); 1.56 (br m, [4H)] ; 1.63 (s, 6H); 2.36 (s, 6H); 2.50 (br m, 8H); 3.29 (s, 2H); 3.58 (s, 2H); 4.15 (br m, 1H); 4.75 (br m, 1H); 5.53 (s, 1H) ; 6.80 (s, 1H) ; 6.96 (s, 1H) ; 7.21 (s, 2H); 7.97 (br s, 1H) ; 8.25 (s, 1H); 8.53 (br s, 1H).
The chemical industry reduces the impact on the environment during synthesis 18592-13-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/18480; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia