Reference of 947533-45-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a article, author is Lakomska, Iwona, introduce new discover of the category.
Platinum(II) Complexes with Bulky Disubstitute Triazolopyrimidines as Promising Materials for Anticancer Agents
Herein, we present dicarboxylate platinum(II) complexes of the general formula [Pt(mal)(DMSO)(L)] and [Pt(CBDC)(DMSO)(L)], where L is dbtp 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine) or ibmtp (7-isobutyl-5-methyl-1,2,4- triazolo[1,5-a]pyrimidine), as prospective prodrugs. The platinum(II) complexes were synthesized in a one-pot reaction between cis-[PtCl2(DMSO)(2)], silver malonate or silver cyclobutane-1,1-dicarboxylate and triazolopyrimidines. All platinum(II) compounds were characterized by FT-IR, and H-1, C-13, N-15 and Pt-195 NMR; and their square planar geometries with one monodentate N(3)-bonded 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine, one S-bonded molecule of dimethyl sulfoxide and one O,O-chelating malonato (1, 2) or O,O-chelating cyclobutane-1,1-dicarboxylato (3, 4) was determined. Additionally, [Pt(CBDC)(dbtp)(DMSO)] (3) exhibited (i) substantial in vitro cytotoxicity against the lung adenocarcinoma epithelial cell line (A549) (IC50 = 5.00 mu M) and the cisplatin-resistant human ductal breast epithelial tumor cell line (T47D) (IC50 = 6.60 mu M); and (ii) definitely exhibited low toxicity against normal murine embryonic fibroblast cells (BALB/3T3).
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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia