Reference of 13223-25-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 3 Synthesis of 2-(4,6-dimethoxypyrimidin-2-yloxy)benzaldehyde di-n-octylacetal (Compound No. 7) To a mixed solvent of 40 ml of n-octanol and 15 ml of benzene, 1 g of salicylaldehyde was added. The mixture was poured into an eggplant-type flask equipped with a SHEALAM cap, followed by purging with nitrogen. After the addition of 0.04 g of dichlorotris(triphenylphosphine)ruthenium, the mixture was reacted under heating at 100 C. for 20 hours. After the completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue thus obtained (0.9 g) was dissolved in 10 ml of DMF, followed by the addition of 0.5 g of 2-chloro-4,6-dimethoxypyrimidine and 0.2 g of potassium carbonate. The resulting mixture was reacted under heating at 110 C. for 3 hours. After the completion of the reaction, the reaction mixture was poured into 100 ml of water, followed by extraction three times, with 50 ml each of ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure. The residue was subjected to chromatography on a silica gel column and then eluated with a 7:3 mixed solvent of n-hexane and ethyl acetate to purify the same, whereby 0.7 g of the target compound, 2-(4,6-dimethoxypyrimidin-2-yloxy)benzaldehyde di-n-octylacetal, was obtained (yield 17%).
According to the analysis of related databases, 13223-25-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsui Toatsu Chemicals, Inc.; US5178662; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia