Synthetic Route of 111196-81-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of 17a-f (7.78 mmol), 1-Boc-piperazine 13(7.78 mmol) in anhydrous ethanol (10 mL)was added triethylamine(15.56 mmol). The mixture was heated to reflux for 12 h. Aftercooling to the ambient temperature, ice-cold water (20 mL) wasadded. The precipitate was separated by filtration, washed withwater (10 mL) and dried to afford 18a-f. The compounds 18a-f wereused to the next step without further purification.
According to the analysis of related databases, 111196-81-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Gong, Ningbo; Huan, Yi; Huang, Haihong; Jiang, Qian; Lei, Lei; Li, Gang; Li, Yan; Lu, Yang; Ma, Chen; Meng, Bingxu; Shen, Zhufang; Sheng, Li; Wang, Weiping; Yuan, Baokun; Zhou, Tian; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia