Electric Literature of 42487-72-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42487-72-9, name is 2-(Diethylamino)-6-methylpyrimidin-4-ol. A new synthetic method of this compound is introduced below.
A mixture of ethyl acetoacetate (0.60 g), 1,1-diethylhydrazine hydrochloride (0.54 g) and potassium carbonate (1.15 g)The material was dissolved in ethanol (5 mL), then refluxed for 20 hours, acetic acid was added to the reaction mixture and the solvent was removed,Water was added to the residue, acetic acid was added, the precipitate was filtered off, washed with water and ethyl acetate, dried,Compound (II) is prepared as shown in formula (II); Compound (II) (5.1 mmol) is dissolved in DMF (15 mL)Potassium carbonate (0.2 g, 5.6 mmol) was added and a mixture of 2-chloroacetic acid ethyl ester (5.6 mmol) was added dropwise.After stirring at room temperature overnight, the mixture was poured into water.The precipitate was filtered off and recrystallized from petroleum ether / acetone to synthesize a compound (III) represented by the formula (III)Compound (III) (10 mmol) and 85% hydrazine hydrate (35 mmol) were refluxed for 6 hours, cooled to room temperature, filtered, washed with ethyl acetate and dried to give(2- (diethylamino) -6-methylpyrimidin-4-yl) oxy) acetohydrazide was obtained as shown in formula (IV); to a 1 mL pressure grade vialCompound (IV) (1 mmol) and various substituted aldehydes (1 mmol) were added to EtOH in Corporation, Boston, USA)(4 mL) is a solvent and the mixture is 150 W, 90 C. in a CEM microwave synthesizer (CEM Corporation, Boston, USA).200 psi irradiation for 2 minutes, the compressed air is passed through the microwave cavity for 2 minutes, the mixture is cooled to room temperature, filtered, the crude solidRecrystallization from ethanol gives the target compound represented by formula (I).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42487-72-9, its application will become more common.
Reference:
Patent; Zhejiang University of Technology; Liu Xinghai; Shen Zhonghua; Wang Qiao; Sun Zhaohui; Tan Chengxia; Weng Jianquan; (15 pag.)CN106831604; (2017); A;,
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