Adding a certain compound to certain chemical reactions, such as: 90905-32-1, 2-Methoxypyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 90905-32-1, blongs to pyrimidines compound. SDS of cas: 90905-32-1
To a suspension of potassium t-butoxide (1.23 g) in methylene chloride (70 [ML,-30C)] was added a solution of [N-BENZYLOXYCARBONYL-A-PHOSPHONOGLYCINE] trimethyl ester (3.63 g) in methylene chloride (15 mL). The resulting solution was stirred 5 min and treated with the 2-methoxy-pyrimidine-5-carbaldehyde (1.0 g) in methylene chloride (15 mL). After stirring for 1.5 h, the reaction was warmed to [0C] and stirred 1 h. The reaction was quickly poured into a sep funnel containing ethyl acetate and water. Brine was added to aid in separation of the layers. The aqueous was extracted with ethyl acetate [(3X)] which were in turn washed with brine, dried over magnesium sulfate, and concentrated. The crude product was recrystallized from hot methanol to give 1.4g of pure material. Mass spec.: 344. [10] (MH) +.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90905-32-1, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia