Electric Literature of 211244-81-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.211244-81-4, name is 2-(Methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one, molecular formula is C8H7N3OS, molecular weight is 193.23, as common compound, the synthetic route is as follows.
2-methylthio-pyrido [2,3-d] pyrimidin-7-one (300mg) (as shown in the formula the compound 4-b) dispersingIn glacial acetic acid (10ml), was added bromine (0.16mL), the reaction mixture was stirred at room temperature 48h. After completion of the reactionDichloromethane was added, filtered, washed with methanol to give a white solid (390mg, 92%) (as defined in formulaThe compound represented by 4-c):
The chemical industry reduces the impact on the environment during synthesis 211244-81-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Pharmaceutical Group Inc.; Wan, Huixin; Xu, Zhiyong; Shi, Chen; Li, Chunli; Xu, Zhenmin; Xia, Guangxin; Ma, Ke; Li, Yufeng; (59 pag.)CN105481858; (2016); A;,
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